How does clear cell carcinoma spread?

Where does clear cell carcinoma spread?

Approximately 25% of ccRCC patients demonstrate distant metastasis at the first diagnosis, while 20% to 50% of metastases occur several years after primary tumor surgery. The most common sites are the lungs (76%), local lymph nodes (66%), bone (42%), and liver (41%).

Can clear cell renal cell carcinoma spread?

Clear cell renal carcinoma is known for its propensity for metastatic spread. Common sites of metastasis are the lungs, bones, lymph nodes, liver, adrenals and brain, but all organs can be affected.

How fast does clear cell carcinoma grow?

Clear cell carcinoma (0.86 cm/year) tended to grow faster than papillary cell carcinoma (0.28 cm/year) (P = 0.066).

How serious is clear cell carcinoma?

Patients with clear cell renal cell carcinoma (CCRCC) tend to have a worse prognosis than patients with other histologic subtypes of RCC, with 5-year disease-specific survival rates of 50-69%, compared with 67-87% for papillary RCC and 78-87% for chRCC.

What is the survival rate of clear cell carcinoma?

The 5-year survival rate for patients with ccRCC is 50-69%. When ccRCC is already large or has spread to other parts of the body, treatment is more difficult and the 5-year survival rate is about 10%.

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What is the most common site of metastasis for RCC?

Patterns of metastases in RCC

The most common sites of metastases were lung (45%), following by bone (30%) and lymph node (22%). Liver metastases were noted in 20% of patients and adrenal metastases were noted in 9% of patients. Brain metastases occurred in approximately 9% of patients (Fig. 1).

What is metastatic clear cell carcinoma?

Metastatic renal cell carcinoma is cancer in your kidneys that has spread to other parts of your body. It’s also called stage IV renal cell cancer. Cancer is harder to treat after it spreads, but it’s not impossible.

Where does RCC metastasis to?

RCC typically metastasizes to the lung, bone, lymph nodes, liver, adrenal glands, and brain (Fig 2) (23), although practically any organ may be affected.

Is clear cell carcinoma hereditary?

When the FLCN gene is mutated, uncontrolled cell growth may result that leads to cancer. Mutated copies of the FLCN gene are passed from parents to children. The syndrome caused by these mutations is inherited in an autosomal dominant fashion.

How is clear cell carcinoma treated?

Treatment often begins with surgery to remove as much of the cancer as possible, and may be followed by radiation therapy , chemotherapy , biological therapy , or targeted therapy.