How does germ cell tumor develop?

How does germ cell tumors happen?

The cause of most germ cell tumors isn’t always known. Doctors do know that some medical conditions can make children more likely to develop them. These include: birth defects that involve the central nervous system, genitals, urinary tract, and spine.

When do germ cell tumors form?

Gonadal germ cell tumors form in the ovaries or the testes. There are two types of germ cell tumors that start in the gonads, or reproductive organs: seminomas, which are slower-growing, and nonseminomas, which are faster-growing tumors. These germ cell tumors typically form during puberty.

Where does germ cell tumor occur?

Germ cell tumors arise in the ovaries (in girls), the testes (in boys), and in several other locations, including the lower back (common in infancy), the abdomen, the chest, and within the brain. Germ cell tumors starting within the brain are discussed further under Brain Tumors.

What are the risk factors for developing germ cell tumors?

Germ Cell Tumor – Childhood: Risk Factors

  • Cryptorchidism. If a child has an undescended testicle, they have a higher risk of developing a testicular seminoma tumor. …
  • Turner syndrome. …
  • Intersex conditions, such as androgen insensitivity syndrome.
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Do germ cell tumors come back?

How do providers treat benign (noncancerous) ovarian germ cell tumors? Healthcare providers remove benign tumors surgically. Sometimes, they need to remove the ovary (or part of the ovary) when removing the tumor. Benign tumors rarely grow back after providers remove them.

What are the signs of germ cell tumor?

Common signs of germ cell tumors include:

  • A mass on your ovaries or testicles.
  • Belly pain and swelling (caused by tumor)
  • Bathroom troubles (a hard time pooping or holding in your pee, if the tumor is near your pelvis)
  • Breast growth, pubic hair, or vaginal bleeding at an earlier age than normal.
  • Belly or chest pain.

Are germ cell tumors genetic?

The cause of germ cell tumors isn’t fully known. Some gene defects passed on from parents to children (inherited) may increase the risk for germ cell tumors. Some genetic syndromes can cause abnormal growth of the male and female reproductive systems.

Are germ cell tumors cancerous?

Ovarian germ cell tumor is a disease in which malignant (cancer) cells form in the germ (egg) cells of the ovary. Germ cell tumors begin in the reproductive cells (egg or sperm) of the body. Ovarian germ cell tumors usually occur in teenage girls or young women and most often affect just one ovary.

Does teratoma respond to chemotherapy?

Mature teratoma is resistant to chemotherapy and radiotherapy.

How do you test for germ cell tumors?

In addition to a physical examination, the following tests may be used to diagnose a germ cell tumor:

  1. Biopsy. A biopsy is the removal of a small amount of tissue for examination under a microscope. …
  2. Blood tests. Alpha-fetoprotein (AFP). …
  3. Ultrasound. …
  4. Computed tomography (CT or CAT) scan. …
  5. Magnetic resonance imaging (MRI).
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Can adults have germ cell tumors?

Extragonadal germ cell tumors are usually seen in children or young adults and typically arise in midline locations. In adults, the most common sites of primary extragonadal germ cell tumors are, in descending order, the mediastinum, retroperitoneum, and cranium.