Is tamoxifen use in postmenopausal breast cancer?

Can you take tamoxifen if you are postmenopausal?

Tamoxifen can be used by both pre- and postmenopausal women. It remains the hormone treatment of choice for premenopausal women.

Why is tamoxifen not used for postmenopausal?

A slight increase in thromboembolic events in postmenopausal women taking tamoxifen has been suggested in some adjuvant trials. Rarely, ocular toxicity and hepatotoxicity are found. The adverse effect of primary importance is the increased incidence of endometrial carcinoma.

Is it necessary to take tamoxifen after breast cancer?

For breast cancer prevention, people are usually advised to take tamoxifen for five years. It’s also prescribed for five years for most patients with early stage, low-risk estrogen receptor-positive breast cancer. For those at higher risk, it can be taken as long as 10 years.

Who should not use tamoxifen?

The increased risk seems to affect women over 50, but not younger women. If you have been diagnosed with uterine cancer or pre-cancer you should not take tamoxifen.

Why you should not take tamoxifen?

Tamoxifen may cause hot flashes and increase the risk of blood clots and stroke. Aromatase inhibitors may cause muscle and joint aches and pains. Less common but more severe side effects of aromatase inhibitors are heart problems, osteoporosis, and broken bones.

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Is tamoxifen for pre or post menopausal?

Tamoxifen, a selective estrogen receptor modulator, is effective in both pre- and postmenopausal women.

How does tamoxifen affect menopause?

Side effects of tamoxifen may include: Menopause-like symptoms, including hot flashes, night sweats and vaginal dryness. Weight gain (more common) or fluid retention (edema). Irregular or loss of menstrual periods.

Does tamoxifen lower your immune system?

Taking hormone therapy does not affect your immune system. Hormone therapies, including tamoxifen, letrozole, anastrozole, exemestane and goserelin, do not affect your risk of getting coronavirus or of becoming seriously ill if you do get it.

How much does tamoxifen reduce the risk of recurrence?

Doctors have long known that five years of tamoxifen reduces recurrence by about half during treatment and by nearly a third over the next five years. Aromatase inhibitors, which work only in postmenopausal women, are even more effective than tamoxifen at reducing recurrence and death from breast cancer.

Can breast cancer come back while on tamoxifen?

Among the women who took tamoxifen for 10 years, the risk of breast cancer returning between 10 and 14 years after starting tamoxifen was 25 percent lower than it was among women who took it for 5 years, and the risk of dying from breast cancer was nearly 30 percent lower.

Has anyone stopped taking tamoxifen?

Janice Hopkins Tanne. A large Irish study of women who were prescribed tamoxifen showed that 22.1% had stopped taking the drug within a year (Cancer 2007 Jan 27, doi: 10.1002/cncr. 22486). Within 3.5 years, the number who had stopped had risen to 35.2%.

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Is there an alternative to taking tamoxifen?

After 10 years of follow-up, a study shows that taking Arimidex for 5 years is better at reducing the risk of hormone-receptor-positive breast cancer recurrence than taking tamoxifen for 5 years.