What does differentiation mean in cells?
Listen to pronunciation. (sel DIH-feh-REN-shee-AY-shun) The process during which young, immature (unspecialized) cells take on individual characteristics and reach their mature (specialized) form and function.
What does it mean when cancer cells are poorly differentiated?
High grade or grade III tumor cells are poorly differentiated. This means that the tumor cells don’t look like normal cells. They’re disorganized under the microscope and tend to grow and spread faster than grade I tumors.
What does differentiated mean in medical terms?
Differentiation: 1 The process by which cells become progressively more specialized; a normal process through which cells mature. This process of specialization for the cell comes at the expense of its breadth of potential. Stem cells can, for example, differentiate into secretory cells in the intestine.
What causes cell differentiation?
Factors involved in triggering cell differentiation include cell signaling, environmental influences and the level of development of the organism. Basic cell differentiation occurs after a sperm cell fertilizes an egg and the resulting zygote reaches a certain size.
What is cell differentiation and why is it important?
Cell differentiation is an important process through which a single cell gradually evolves allowing for development that not only results in various organs and tissues being formed, but also a fully functional animal.
What is differentiation and Anaplasia?
Anaplasia is a qualitative alteration of differentiation. Anaplastic cells are typically poorly differentiated or undifferentiated, and exhibit advanced cellular pleomorphism. In fact, anaplasia and pleomorphism are sometimes incorrectly used as synonyms. Pleomorphism refers to variation in size and shape of cells.
Are malignant cells well differentiated?
A term used to describe cells and tissue that have mature (specialized) structures and functions. In cancer, well-differentiated cancer cells look more like normal cells under a microscope and tend to grow and spread more slowly than poorly differentiated or undifferentiated cancer cells.
Does undifferentiated mean cancer?
Undifferentiated cancer: A cancer in which the cells are very immature and “primitive” and do not look like cells in the tissue from it arose. As a rule, an undifferentiated cancer is more malignant than a cancer of that type which is well differentiated. Undifferentiated cells are said to be anaplastic.
What does it mean when cells are undifferentiated?
(un-DIH-feh-REN-shee-AY-ted) A term used to describe cells or tissues that do not have specialized (“mature”) structures or functions. Undifferentiated cancer cells often grow and spread quickly.
What is the meaning of well differentiated?
Pathologists use the term well differentiated to describe a tumour made up of cells that look very similar to the normal, non-cancerous cells found in that area of the body. A tumour can be described as well differentiated based on the shape, size, and colour of the cells or by the way the cells stick together.
Can poorly differentiated cancer be cured?
It is now clear that some patients with poorly differentiated carcinoma of unknown primary site have extremely responsive neoplasms, and some are curable with combination chemotherapy.