Which type of cells are least sensitive to chemotherapy?
Stem cells in particular, are thought to show significantly decreased sensitivity to both chemotherapy and targeted drugs (7–9).
Which cells are affected in cancer?
Carcinomas that begin in different epithelial cell types have specific names: Adenocarcinoma is a cancer that forms in epithelial cells that produce fluids or mucus. Tissues with this type of epithelial cell are sometimes called glandular tissues. Most cancers of the breast, colon, and prostate are adenocarcinomas.
Which types of cancers are more likely to be altered by chemotherapy?
The cancers most often linked to chemo are myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). Sometimes, MDS occurs first, then turns into AML. Acute lymphocytic leukemia (ALL) has also been linked to chemo. Chemo is known to be a greater risk factor than radiation therapy in causing leukemia.
What is a common side effect of chemotherapy because it targets fast growing cells?
The fast-growing normal cells most likely to be affected by chemotherapy are blood cells forming in the bone marrow, and cells in the digestive tract, reproductive system, and hair follicles. Common side effects of chemotherapy include fatigue, nausea, diarrhea, mouth sores, hair loss, and anemia.
What type of cells are most vulnerable to radiation and why?
Cells in late G2 and mitosis (M-phase) are the most sensitive to radiation, and cells in late synthesis (S-phase) are the most resistant (Fig. 23.10).
Are highly specialized cells radiosensitive?
Muscle cells, which are highly specialized and incapable of cell division, are sensitive to radiation than are lymphocytes (white blood cells), which are unspecialized and capable of cell division.
What is radiosensitive cells?
Radiosensitivity is the relative susceptibility of cells, tissues, organs, organisms, or other substances to the injurious action of radiation. In general, it has been found that cell radiosensitivity is directly proportional to the rate of cell division and inversely proportional to the degree of cell differentiation.
How does chemotherapy affect normal cells and cancer cells?
Chemotherapy is the use of drugs to destroy cancer cells. It usually works by keeping the cancer cells from growing, dividing, and making more cells. Because cancer cells usually grow and divide faster than normal cells, chemotherapy has more of an effect on cancer cells.