What are the main aetiologies of gastric cancer?
The main cause of stomach cancer is a genetic mutation (change) in the cells of the stomach, which causes the cells to grow rapidly and eventually form a tumor. Risk factors that can increase a person’s chance of getting stomach cancer include: Family history. Smoking.
What is the Lauren classification?
The Lauren classification is based on how the gastric tissue looks and behaves when examined under a microscope. This is the system most often used to describe how adenocarcinoma tumours, the most common type of stomach cancer, look and behave.
What is the most common location for gastric carcinoma?
The site of stomach cancer is classified on the basis of its relationship to the long axis of the stomach. Approximately 40% of cancers develop in the lower part, 40% in the middle part, and 15% in the upper part; 10% involve more than one part of the organ.
Is H pylori cause cancer?
Long-term infection of the stomach with Helicobacter pylori (H pylori) can cause ulcers. It can also inflame and damage the inner layer of the stomach. Some of these changes could lead to cancer over time, especially cancer in the lower part of the stomach.
WHO histological classification of gastric tumors?
The 2010 WHO classification recognizes four major histologic patterns of gastric cancers: tubular, papillary, mucinous and poorly cohesive (including signet ring cell carcinoma), plus uncommon histologic variants (24).
What is the most common GI cancer?
“Colorectal cancers are the most common and most treatable GI cancers in the United States,” says Yale Medicine’s Jeremy Kortmansky, MD, a medical oncologist. “About 5 to 10 percent occur from an inherited genetic risk factor, but the remaining cases happen sporadically.
What is signet ring cell adenocarcinoma?
Signet ring cell carcinoma (SRCC) is a rare form of highly malignant adenocarcinoma that produces mucin. It is an epithelial malignancy characterized by the histologic appearance of signet ring cells.
What is poorly cohesive carcinoma?
Poorly cohesive gastric carcinoma (dyscohesive carcinoma, carcinoma with a lack of intercellular connections) is a malignant tumour of epithelial origin, characterized by diffuse distribution of tumour cells, isolated from each other or in small groups.
What does moderately differentiated adenocarcinoma mean?
This means that the tumor cells don’t look like normal cells. They’re disorganized under the microscope and tend to grow and spread faster than grade I tumors. Cancer cells that don’t look well-differentiated or poorly differentiated are called moderately differentiated, or grade II.
What is leather bottle stomach?
Linitis plastica spreads to the muscles of the stomach wall and makes it thicker and more rigid. This means that the stomach can’t hold as much and doesn’t stretch or move as it should when you’re digesting food. This stiff walled stomach is sometimes called a leather bottle stomach.