What percentage is considered ER positive?
Guidelines for the use of chemotherapy and endocrine therapy recently recommended that estrogen receptor (ER) status be considered positive if ≥1% of tumor cells demonstrate positive nuclear staining by immunohistochemistry. In clinical practice, a range of thresholds are used; a common one is 10% positivity.
Is it better to be ER positive or negative?
Hormone receptor-positive cancers tend to grow more slowly than those that are hormone receptor-negative. Women with hormone receptor-positive cancers tend to have a better outlook in the short-term, but these cancers can sometimes come back many years after treatment.
What percentage of breast cancers express the Oestrogen receptor?
A majority of breast cancer tumors express estrogen receptor (ER) and/or progesterone receptor (PR); however, the percentage of cancer cells expressing these receptors can range from 0-100%.
Is normal breast tissue ER positive?
Median percentages of ER-positive, PR-positive, and Ki67-positive cells in histopathologically normal breast tissue were 10, 6.7, and 4.2%, respectively, among these women with a previous diagnosis of BBD.
Does ER PR positive need chemo?
Most instances of estrogen receptor (ER)-positive, HER2-negative, node-negative breast cancer <1 cm (T1b), and all cancers ≤0.5 cm (T1a), have a good prognosis with endocrine therapy alone, and do not typically require adjuvant chemotherapy.
Can you be ER negative and PR positive?
Some have argued that the ER-negative/PR-positive subtype is biologically implausible given the coexpression and pathways of the ER and PR in breast cancer,2 and other studies have been unable to reproduce the ER-negative/PR-positive subtype using alternative techniques.
What happens if ER PR is positive?
Tumors that are ER/PR-positive are much more likely to respond to hormone therapy than tumors that are ER/PR-negative. You may have hormone therapy after surgery, chemotherapy, and radiation are finished. These treatments can help prevent a return of the disease by blocking the effects of estrogen.
Is it better to be HER2 positive or negative?
Is HER2-positive breast cancer good or bad? HER2-positive cancer tends to be poorer in terms of prognosis than HER2-negative cancer because: It grows faster. It is more likely to spread to the lymph nodes fast.
Does HER2-negative require chemo?
Hormonal therapy is considered the standard initial treatment for HER2-negative metastatic breast cancer that is also hormone receptor-positive, and is often given in combination with targeted therapy. However, chemotherapy may also be given. A clinical trial may also be an option for treatment at any stage.
What does it mean to be ER positive?
Describes cells that have a protein that binds to the hormone estrogen. Cancer cells that are ER positive may need estrogen to grow. These cells may stop growing or die when treated with substances that block the binding and actions of estrogen. Also called estrogen receptor positive.
What does ER positive PR-negative mean?
If breast cancer cells have estrogen receptors, the cancer is called ER-positive breast cancer. If breast cancer cells have progesterone receptors, the cancer is called PR-positive breast cancer. If the cells do not have either of these 2 receptors, the cancer is called ER/PR-negative.
What does ER PR Her2 mean?
ER = estrogen receptor, Her2 = human epidermal growth factor receptor 2, PR = progesterone receptor, + = positive, − = negative.