Why is tamoxifen given after chemotherapy?

When do you start tamoxifen after chemo?

Tamoxifen can be started either after surgery (adjuvant therapy) or before surgery (neoadjuvant therapy) and is usually taken for 5 to 10 years. This drug is used mainly for women with early-stage breast cancer who have not yet gone through menopause.

Can you take tamoxifen during chemotherapy?

Based on a median follow-up of 8.5 years, the intergroup data showed that giving tamoxifen concurrently with chemotherapy reduces both disease-free survival and overall survival compared to giving chemotherapy followed by tamoxifen.

Does tamoxifen stop cancer from coming back?

Tamoxifen can: reduce the risk of breast cancer coming back by 40% to 50% in postmenopausal women and by 30% to 50% in premenopausal women. reduce the risk of a new cancer developing in the other breast by about 50%

Does tamoxifen prevent metastasis?

When used appropriately, it may reduce the risk of breast cancer developing in the other breast by roughly 50 percent. 1 The drug may also be used to reduce the chance that certain women will develop breast cancer in the first place, or to slow the growth of metastatic breast cancer.

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Is tamoxifen really necessary?

Tamoxifen is a highly effective breast cancer treatment. It may significantly lower your risk of breast cancer recurrence or invasive breast cancer. People who are at high risk for breast cancer may take tamoxifen to reduce their chances of getting the disease.

What is an indication for taking tamoxifen?

Indications. Tamoxifen is indicated for the treatment of breast cancer in a variety of settings. It should be noted that evidence suggests that patients with estrogen receptor-positive tumors are more likely to benefit from tamoxifen. [1] Tamoxifen also has many off-labeled uses, and they may require additional data.

Is tamoxifen better than chemotherapy?

At a median follow-up of 5 years tamoxifen appeared to be more effective than chemotherapy, the difference being highly significant in postmenopausal women. The addition of chemotherapy to tamoxifen was not able to significantly improve the results achieved by tamoxifen alone, irrespective of menopausal status.

Is tamoxifen A immunosuppressant?

Whilst its role in breast cancer treatment may be diminishing, a growing body of evidence has defined a novel role for tamoxifen as an immune modulator.

Do you lose your hair with tamoxifen?

No one goes bald from Tamoxifen, but some people do experience thinning hair. Like hair thinning, a lowered libido is common postmenopause and in the setting of reduce estrogen. Some women also attribute weight gain to Tamoxifen.

Can breast cancer come back while on tamoxifen?

Among the women who took tamoxifen for 10 years, the risk of breast cancer returning between 10 and 14 years after starting tamoxifen was 25 percent lower than it was among women who took it for 5 years, and the risk of dying from breast cancer was nearly 30 percent lower.

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Can you take vitamin D with tamoxifen?

No interactions were found between tamoxifen and Vitamin D3. This does not necessarily mean no interactions exist.

What is the most common secondary cancer after breast cancer?

The most common second cancer in breast cancer survivors is another breast cancer.

Second Cancers After Breast Cancer

  • Stomach cancer.
  • Colon cancer.
  • Uterine cancer.
  • Ovarian cancer.
  • Thyroid cancer.
  • Soft tissue cancer (sarcoma)
  • Melanoma of the skin.
  • Acute myeloid leukemia (AML)