What type of drug is bisphosphonate?
What are Bisphosphonates? Bisphosphonates are a group of medicines that slow down or prevent bone loss, strengthening bones. Bisphosphonates inhibit osteoclasts which are responsible for breaking down and reabsorbing minerals such as calcium from bone (the process is known as bone resorption).
Why do cancer patients take bisphosphonates?
Bisphosphonates are drugs that help prevent or slow down bone thinning (osteoporosis). They can help to treat some types of cancer that cause bone damage. You might hear bisphosphonates called bone hardening or bone strengthening treatment. They are also a treatment for high levels of calcium in your blood.
Is zoledronic acid chemotherapy?
Zoledronic acid (Zometa) is not cancer chemotherapy, and it will not slow or stop the spread of cancer. However, it can be used to treat bone disease in patients who have cancer.
Do bisphosphonates weaken your immune system?
This work suggests that bisphosphonates have the potential to depress the innate immune system for a prolonged time, possibly contributing to the pathogenesis of BRONJ.
What are the risks of taking bisphosphonates?
Side effects for all the bisphosphonates (alendronate, ibandronate, risedronate and zoledronic acid) may include bone, joint or muscle pain. Side effects of the oral tablets may include nausea, difficulty swallowing, heartburn, irritation of the esophagus (tube connecting the throat to the stomach) and gastric ulcer.
Who should not take bisphosphonates?
Don’t take bisphosphonates if you:
- Are allergic to them.
- Have disorders of the food pipe (esophagus), including tears, holes, narrowing, or difficulty swallowing.
- Have severe kidney disease.
- Can’t sit in an upright position for at least 30 minutes.
- Have low levels of calcium in your bloodstream.
Should I take bisphosphonates for breast cancer?
Bisphosphonates slow down or prevent bone damage. You may hear bisphosphonates called bone-hardening or bone-strengthening treatment. Research has shown bisphosphonates may reduce the risk of breast cancer spreading to the bones and elsewhere in the body in post-menopausal women being treated for primary breast cancer.
Do you have to take calcium with bisphosphonates?
Therefore, patients receiving bisphosphonates should take supplemental calcium and vitamin D. However, calcium and other mineral (eg, magnesium, iron) supplements can interfere with the absorption of bisphosphonates, and they should not be taken for at least one hour after taking oral bisphosphonates.
Are bisphosphonates worth taking?
The higher your fracture risk, the more likely it is that bisphosphonates can help prevent a fracture. The lower your fracture risk, the less likely it is that these medicines can help prevent a fracture. If you have osteoporosis or you have had a fracture, taking bisphosphonates lowers your risk of a fracture.
Does zoledronic acid cause weight gain?
Tell your doctor if you have serious side effects of Reclast including urinating less than usual or not at all; drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, swelling, weight gain, shortness of breath, muscle spasms, numbness or tingling (especially around your mouth), …
Is zoledronic acid an immunosuppressant?
Thanks to its ability to decrease Ras/ERK1/2 activity, which is responsible for both Pgp-mediated chemoresistance and IDO-mediated immunosuppression, zoledronic acid is an effective chemo-immunosensitizing agent in HMM cells.
Does zoledronic acid make you tired?
This treatment may cause changes in the blood. For example, it can cause low levels of red blood cells (anaemia). Symptoms of anaemia include feeling very tired and breathless.