Your question: What type of chemotherapy is cytarabine?

What class of chemo is cytarabine?

Cytarabine is in a class of medications called antimetabolites. It works by slowing or stopping the growth of cancer cells in your body.

What are the 6 classes of chemotherapy drugs?

Some of the well known classes of cancer chemotherapy agents include alkylating agents, plant alkaloids, antimetabolites, anthracyclines, topoisomerase inhibitors and corticosteroids.

  • Normal cell cycle. …
  • Alkylating agents. …
  • Antimetabolites. …
  • Anthracyclines. …
  • Topoisomerase inhibitors. …
  • Plant alkaloids. …
  • Corticosteroids.

What is the mechanism of action of cytarabine?

Mechanism of Action

Cytarabine is a pyrimidine analog and is also known as arabinosylcytosine (ARA-C). It is converted into the triphosphate form within the cell and competes with cytidine to incorporate itself in the DNA. The sugar moiety of cytarabine hinders the rotation of the molecule within the DNA.

Why does cytarabine work better on cancer cells?

These cells spread, destroying nearby tissues. Cytarabine works by stopping the cancer cells from multiplying. It does this by inhibiting the production of the cells’ genetic material, DNA and RNA. Both DNA and RNA are needed for growth and multiplication of cells.

THIS IS INTERESTING:  Does oncologist perform surgery?

Do you lose your hair with cytarabine?

This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.

Does cytarabine cause hair loss?

This medicine may cause a temporary loss of hair in some people. After treatment with cytarabine has ended, normal hair growth should return.

Is chemotherapy A antibiotic?

Anti-tumor antibiotics

These drugs are not like the antibiotics used to treat infections. They work by changing the DNA inside cancer cells to keep them from growing and multiplying.

What is the most common chemotherapy drug?

The most common chemotherapy drugs and combinations used to treat breast cancer are listed below in alphabetical order:

  • AC.
  • Capecitabine (Xeloda)
  • Carboplatin.
  • CMF.
  • Docetaxel (Taxotere)
  • EC.
  • EC-T (a combination of EC and paclitaxel)
  • E-CMF.

How do antitumor antibiotics work?

Antitumor antibiotic

Antitumor antibiotics are cell cycle nonspecific. They act by binding with DNA and preventing RNA (ribonucleic acid) synthesis, a key step in the creation of proteins, which are necessary for cell survival. They are not the same as antibiotics used to treat bacterial infections.

Is Cytarabine an immunosuppressant?

Immunosuppressive Action

This suppression was obtained during both primary and secondary antibody responses. Cytarabine also suppressed the development of cell-mediated immune responses such as delayed hypersensitivity skin reaction to dinitrochlorobenzene.

Which phase of the cell is most affected by Cytarabine?

Its mode of action is due to its rapid conversion into cytosine arabinoside triphosphate, which damages DNA when the cell cycle holds in the S phase (synthesis of DNA). Rapidly dividing cells, which require DNA replication for mitosis, are therefore most affected.

THIS IS INTERESTING:  Can you go to chemo alone?

How often is Cytarabine given?

Intermittent dosing: Cytarabine may be given as intermittent intravenous doses of 3-5 mg/kg daily, for five consecutive days. This course of treatment can be repeated after an interval of 2 to 9 days and repeated until the therapeutic response or toxicity is exhibited.

How long do cytarabine fevers last?

The median duration of fever was 10.15 h (range 1–72 h). There were fever-free episodes between fever spikes in 11 consolidation cycles.

Where does cytarabine come from?

The isolation of C-nucleosides from the Caribbean sponge, Cryptotheca crypta, four decades ago, provided the basis for the synthesis of cytarabine, the first marine-derived anticancer agent to be developed for clinical use. Cytarabine is currently used in the routine treatment of patients with leukaemia and lymphoma.

When was cytarabine first used?

This paper reviews the development of therapy for acute myelogenous leukemia that in 1973 led to the regimen of 7days of continuous intravenous arabinosylcytosine (cytarabine) and the first 3 concurrent days of intravenous daunorubicin, given the nickname “7+3.” The state of leukemia treatment in the 1950s, 1960s and …