Is chemotherapy apoptosis or necrosis?


Is chemotherapy A necrosis?

Chemo drugs often kill cancer cells via necrosis, resulting in release of cell debris and various immunogenic components to stimulate immune functions and inflammatory response of the patient, which in turn will elicit cancer cell specific killing.

Does chemotherapy cause apoptosis?

The faster that cancer cells divide, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink. They also induce cell suicide (self-death or apoptosis). Chemotherapy drugs that kill cancer cells only when they are dividing are called cell-cycle specific.

How does chemotherapy induce apoptosis?

Several reports have suggested that anticancer drugs kill susceptible cells by inducing expression of death receptor ligands, especially Fas ligand (FasL). Other reports have indicated that chemotherapeutic agents trigger apoptosis by inducing release of cytochrome c from mitochondria.

Why is necrosis bad?

Cells release a bunch of hazardous molecules when they die by necrosis. A new theory describes that necrotic death and chronic inflammation may foster the onset and growth of tumors. We all shudder about untimely deaths or those that we were not prepared for. As such we perceive such “unscheduled” deaths as dangerous.

What necrosis means?

Necrosis is the death of body tissue. It occurs when too little blood flows to the tissue. This can be from injury, radiation, or chemicals.

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What chemotherapy drugs cause apoptosis?

Chemotherapeutic Agents Kill Susceptible Cells by Apoptosis

Some Agents Associated With Apoptosis Cancer Types Susceptible to Apoptosis
. . .
Vincristine Nitrogen Mustard Colon carcinoma
cis-Platinum Methotrexate Prostate cancer
Cyclophosphamide Chlorambucil Miscellaneous adenocarcinomas

Why is apoptosis preferred over necrosis?

Why i prefer necrosis (now this time i mean the necrosis following chemotherapy) to apoptosis is that to kill the tumor cell together with its microenvironment may be more important than killing the tumor cell only. To achieve this, massive cell killing effect (using necrotic agents!)

Which types of cancers are more likely to be altered by chemotherapy?

The cancers most often linked to chemo are myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML). Sometimes, MDS occurs first, then turns into AML. Acute lymphocytic leukemia (ALL) has also been linked to chemo. Chemo is known to be a greater risk factor than radiation therapy in causing leukemia.

Why do chemotherapy patients lose their hair?

Why does chemotherapy cause hair loss? The reason chemotherapy can cause hair loss is that it targets all rapidly dividing cells — healthy cells as well as cancer cells. Hair follicles, the structures in the skin from which hair grows, include some of the fastest-growing cells in the body.

How do you stimulate apoptosis?

Induction of apoptosis by dietary chemopreventive agents. The extrinsic pathway is initiated by ligation of transmembrane death receptors (CD95, TNF receptor and TRAIL receptor) to activate membrane-proximal (activator) caspase-8 via the adaptor molecule FADD. This in turn cleaves and activates effector caspase-3.