What are the side effects of ADT for prostate cancer?

What is the most common complication with ADT?

Weight gain and increased body fat mass are common complications of ADT. This weight gain coupled with low activity levels secondary to fatigue and changes in lipid levels may increase the risk of cardiovascular toxicities.

How bad is ADT therapy?

There are serious side effects with long-term ADT – things that testosterone normally helps protect you from – including thinning of bones, loss of muscle mass, weight gain, loss of libido, hot flashes, mood changes, depression and, our main subject here, the risk of cognitive impairment.

Which side effect indicates excessive androgen therapy?

A significant side effect associated with ADT is loss of bone density or bone mass. Bone loss increases the risk of osteoporosis, bone fracture, pain, hospitalization, and immobility, and increases medical costs.

What are the effects of androgen deprivation therapy?

Patient summary: Androgen deprivation therapy is a critical component of the management of aggressive and advanced prostate cancer, but it causes adverse effects including bone loss, metabolic changes, gynecomastia, muscle loss, hot flashes, and possibly increased cardiovascular events.

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How long does it take to recover from ADT?

After ADT, many patients had normal testosterone levels (>6 nmol/L) until 6 weeks, and testosterone recovery reached 35% at 12 weeks (mean, 11.4 nmol/L), 85% at 18 weeks, and 89% at 24 weeks. The median time for testosterone recovery was 13 weeks.

Is ADT a form of chemotherapy?

Chemotherapy is now often recommended in combination with ADT as the initial treatment for males whose cancer has already spread outside of the prostate, typically to the bones or other organs. Chemotherapy given when treatment is first started may improve survival over ADT alone.

Is ADT palliative care?

ADT remains a palliative treatment with minimal effect on survival, with almost all patients dying from prostate cancer having hormone-refractory prostate cancer with castrate levels of testosterone.

Does ADT shrink prostate?

Generally, reports showed that after 3 to 8 months of ADT, including an LHRH agonist with or without an antiandrogen, results in a prostate size decrease from 20%–50% [16-18].

What is ADT prostate?

Prostate cancer needs testosterone to grow. Reducing how much testosterone your body makes may slow the cancer’s growth or shrink the cancer temporarily. Testosterone is an androgen (male sex hormone), so this treatment is called androgen deprivation therapy (ADT).

Does ADT cause joint pain?

These results suggest that hand joint pain is the most characteristic symptom associated with the ADT. The mean duration from the initiation of ADT was 23.7 (1–84) months until the onset of hand joint symptoms.

Do anti androgens cause erectile dysfunction?

Loss of libido and erectile dysfunction (ED) are well-known side effects of this treatment and are usually attributed to the decrease in testosterone levels.

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What does hormone therapy do to a man?

Hormone therapy lowers the amount of testosterone in the body and this affects your ability to have and maintain an erection. This may get better within 3 to 12 months after the treatment ends. For some men, erection problems are permanent. It depends on the drug you are having and how long you have been taking it.