Which chemotherapy drug causes hemorrhagic cystitis?

Which cytotoxic agent causes hemorrhagic cystitis?

Hemorrhagic cystitis is inflammation of the urinary bladder lining that can be a severe complication of cancer or its treatment. Oxazophosphorine-based alkylating agents, such as cyclophosphamide and ifosfamide, are the most common cytotoxic agents associated with this disorder.

Can Cytoxan cause hemorrhagic cystitis?

Cyclophosphamide is the most common cause of hemorrhagic cystitis in the oncologic population. The urotoxicity observed with cyclophosphamide is due to its liver metabolite acrolein, which is excreted in the urine.

Can chemotherapy cause cystitis?

Specifically, some chemotherapy drugs, treatments delivered into your bladder and/or radiation to the pelvis can cause an irritation to the lining of your bladder, called cystitis. Cystitis can be severe, causing your bladder to bleed and increasing your risk of infection.

Can carboplatin cause hemorrhagic cystitis?

A review of the literature shows a previous case in which high doses of carboplatin were implicated as the cause of hemorrhagic cystitis, presumably by toxicity to transitional epithelium of the bladder.

Does cisplatin cause hemorrhagic cystitis?

All other causes were ruled out and it is therefore likely that the agent in this case was cisplatin, which has never had haemorrhagic cystitis reported as a side effect.

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How does Mesna prevent hemorrhagic cystitis?

Administration of Mesna (2-mercaptoethane sulfonate sodium) before initiation of cyclophosphamide can prevent hemorrhagic cystitis by binding to and neutralizing acrolein.

What drug is administered with cyclophosphamide to prevent hemorrhagic cystitis?

Mesna is an FDA-approved drug used as a prophylactic medication in reducing the incidence of ifosfamide and cyclophosphamide-induced hemorrhagic cystitis.

Why cyclophosphamide causes hemorrhagic cystitis?

Cyclophosphamide causes hemorrhagic cystitis by renal excretion of its hepatic metabolite, acrolein, which is urotoxic.

What is vincristine made from?

Vincristine belongs to a class of chemotherapy drugs called plant alkaloids. Plant alkaloids are made from plants. The vinca alkaloids are made from the periwinkle plant (catharanthus rosea). The taxanes are made from the bark of the Pacific Yew tree (taxus).

What causes hemorrhagic cystitis?

Hemorrhagic cystitis results from damage to the bladder’s transitional epithelium and blood vessels by toxins, viruses, radiation, drugs (in particular, chemotherapeutic drugs), bacterial infections, or other disease processes.

Is blood in urine cystitis?

Cystitis means inflammation of your bladder. If you have hemorrhagic cystitis (HC), you have signs and symptoms of bladder inflammation along with blood in your urine.

Are UTIS common during chemo?

However, if you are undergoing chemotherapy, or are elderly, you may be more susceptible to the urinary tract infection spreading throughout the urinary tract to the kidneys (pyelonephritis) or into the bloodstream (urosepsis).