What is the role of interferons in the treatment of cancer?
Interferons are made in the body by white blood cells and other cells, but they can also be made in the laboratory to use as treatments for different diseases. In cancer therapy, interferons may help keep cancer cells from growing and may help kill cancer cells.
Why are the patients given alpha interferon?
Alpha interferon is a cytokine produced by the innate immune system in response to environmental exposures including viral infections. Alpha interferon in various formulations has been developed as therapy of several forms of cancer and viral infections, but its major use has been as therapy of chronic hepatitis C.
What is interferon treatment used for?
Interferon alfa-2b injection is used to treat hepatitis B and C, lymphoma (lymph node cancer), malignant melanoma (skin cancer), genital warts, hairy cell leukemia (blood cell cancer), and Kaposi sarcoma (AIDS-related tumor). Interferons are substances produced by cells in the body to help fight infections and tumors.
Can cancer be detected by alpha interferon?
In the 35 years since the discovery of interferon, significant biological activity has been described for interferon-alpha (IFN alpha) in various cancers, particularly haematological malignancies such as hairy cell leukaemia and chronic myelogenous leukaemia.
Why are interferons so important?
Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs).
Which interferon is used during cancer therapy?
Interferons can be made in a laboratory to help your immune system fight cancer. They may also slow the growth of cancer cells. The most common type of interferon used in cancer treatment is called interferon alpha (Roferon-A [2a], Intron A [2b], Alferon [2a]).
Why are some patients treated with alpha interference?
Interferons can help cells to defend themselves against viral infection and are used in the treatment of some cancers to boost the body’s ability to eliminate cancer cells. can worsen existing heart, kidney, liver, and mental health problems.
How is interferon alpha administered?
This medication is given by injection into a muscle or under the skin as directed by your doctor. Rotate the injection site each time you inject this medication to prevent soreness. It may also be given by injection into a vein or directly into a lesion, usually by a health care professional.
What produces interferon alpha?
Alpha interferon is produced by white blood cells other than lymphocytes, beta interferon by fibroblasts, and gamma interferon by natural killer cells and cytotoxic T lymphocytes (killer T cells).
How often is interferon given?
Interferon beta-1a subcutaneous injection comes as a solution (liquid) in a prefilled syringe or a prefilled automatic injection device to inject subcutaneously (under the skin). It is usually injected three times a week.
How do interferons protect us?
Interferons protect non-infected cells from further viral infections by creating cytokine barriers. They also inhibit cellular proliferation and modulate the immune system of the organism.
What do interferons do in the immune system?
Interferons are proteins that are part of your natural defenses. They tell your immune system that germs or cancer cells are in your body. And they trigger killer immune cells to fight those invaders.