Why is filgrastim given to chemotherapy?

Why is filgrastim given after chemotherapy?

Filgrastim injection products (Granix, Neupogen, Nivestym, Zarxio) are used to decrease the chance of infection in people who have non myeloid cancer (cancer that does not involve the bone marrow) and are receiving chemotherapy medications that may decrease the number of neutrophils (a type of blood cell needed to …

Why is filgrastim given to cancer?

Filgrastim helps the bone marrow to make new white blood cells. When certain cancer medicines are used to fight cancer cells, they also affect the white blood cells that fight infections. Filgrastim is used to prevent or reduce the risk of infections while you are being treated with cancer medicines.

What is the mechanism of action of filgrastim?

Filgrastim binds to the G-CSF receptor and stimulates the production of neutrophils in the bone marrow Label. Colony-stimulating factors are glycoproteins which act on hematopoietic cells by binding to specific cell surface receptors, in turn, stimulating proliferation and differentiation 9.

What are the indications for filgrastim?

NEUPOGEN (filgrastim) is approved for 5 indications in the following patient populations:

  • Chemotherapy-induced Febrile Neutropenia.
  • Acute Myeloid Leukemia.
  • Cancer Patients Receiving Bone Marrow Transplant.
  • Peripheral Blood Progenitor Cell Collection and Engraftment.
  • Severe Chronic Neutropenia.
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When should you not give filgrastim?

Filgrastim Precautions:

The manufacturer recommends that the first dose of filgrastim be given no sooner than 24 hours after chemotherapy. Your doctor will discontinue therapy with filgrastim when your white blood cell count has reached acceptable levels.

How long does bone pain last after filgrastim?

Bone pain caused by Neulasta lasts at least 8 days for 49% of the patients, and most likely longer for a large number of patients.

How long does it take for filgrastim to wear off?

Neulasta is a long lasting medicine, with peak levels achieved 24 hours after injection, levels drop considerably over the first 7 days and after 14 days there is only a small amount remaining in the body.

Does Filgrastim need to be given at the same time?

Filgrastim is most often given as a subcutaneous injection (SQ, given under the skin), but it can be given directly into a vein (intravenous, IV). It is given once a day, preferably at the same time of day, until the neutrophil count returns to normal.